Men's March Madness by the numbers: No. 16 seeds are 2-154. So, yes, we're saying there's a chance

The first two days of the NCAA Tournament are for the little guys. Teams from under-the-radar conferences that have rarely, if ever, experienced March Madness get to test themselves against the nation's elite. The Retrievers lost 50-43 to Kansas State in the second round and haven't been back.

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https://sports.yahoo.com/article/mens-march-madness-numbers-no-172301246.html